| 发明名称 |
Hepatitis A virus vaccine. |
| 摘要 |
<p>A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen purification conditions, to yield a >95% pure HAV on the basis of protein. Further processing steps yield an inactivated HAV vaccine formulation which is immunogenic, well tolerated, and efficacious in protection against infection by virulent HAV. The product content of protein, carbohydrate, lipid, DNA and RNA is characterized. <IMAGE></p> |
| 申请公布号 |
EP0583142(A2) |
申请公布日期 |
1994.02.16 |
| 申请号 |
EP19930306223 |
申请日期 |
1993.08.06 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
JUNKER, BETH;LEWIS, JOHN A.;OLIVER, CYNTHIA NEWELL;ORELLA, CHARLES J.;SITRIN, ROBERT D.;ABOUD, ROBERT A.;AUNINS, JOHN G.;BUCKLAND, BARRY C.;DEPHILLIPS, PETER A.;HAGEN, ANNA J.;HENNESSEY JR., JOHN P. |
| 分类号 |
A61K39/00;A61K;A61K35/76;A61K39/012;A61K39/29;A61P31/12;C12N;C12N7/00;C12N7/01;C12N7/02;C12N7/06;C12N15/63;(IPC1-7):C12N7/02 |
主分类号 |
A61K39/00 |
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