Peptides derived from trifluoromethylketones process for preparing them and pharmaceutical compositions containing them

摘要

Peptide derivatives of trifluoromethyl ketones of formula (I), their hydrates, enantiomers, diastereoisomers, epimers, and salts are new. R1, R2 = 1-6C alkyl or 3-7C cycloalkyl; R3 = H, 1-6C alkyl or 3-7C cycloalkyl; R4 = halo, or 1-6C alkyl or alkoxy; R5 = 1-6C alkyl; X, Y = CO or SO2; n = 1, 2, or 3; p = 0 or 1; Z = S or O; A = a gp. of formula (i) or -NR6-CHR7-; A1 with the N and CH forms a 2-azabicyclo(2,2,2)octane, 2-aza bicyclo(2,2,1)heptane, perhydroindole, perhydroisoindole, indoline, isoindoline, perhydroquinoline, perhydroisoquinoline, 1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydroquinoline, cyclopenta(b)pyrrolidine, 1,3-thiazolidine, or pyrrolidine ring, R6 = H, 1-6C alkyl, 3-6C cycloalkyl, or indan-2-yl, R7 = H, or 1-6C alkyl.