摘要 |
The compounds of the following formula: wherein R, R<SUP>2</SUP>, R<SUP>3 </SUP>and A have the meanings given in the specification, are endowed with selective A<SUB>3 </SUB>adenosine receptor antagonist activity. These compounds can be used in a pharmaceutical composition to treat disorders caused by excessive activation of the A<SUB>3 </SUB>receptor, or can be used in a diagnostic application to determine the relative binding of other compounds to the A<SUB>3 </SUB>receptor. The compounds can be labeled, for example with fluorescent or radiolabels, and the labels used in vivo or in vitro to determine the presence of tumor cells which possess a high concentration of adenosine A<SUB>3 </SUB>receptors.
|