Surface coated structures and methods

摘要

The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide, optionally having a polyethylene glycol moiety covalently attached to the peptide, is bound to a substrate. The disclosed methods and composition are useful for reducing the frictional coefficient, inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.

主权项

1. A method of treating a pipe to reduce the frictional drag of fluid flowing through the pipe, comprising
introducing into the pipe, a liquid carrying a conjugate of (i) a D-form or retro-inverso synthetic pilin peptide containing a disulfide loop of a C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin and containing 0-10 additional residues on either or both the N- or C-terminal side of the loop and (ii) a polyethylene glycol moiety, in an amount of conjugate effective to reduce the frictional drag of fluid flowing through the pipe by attachment of the pilin peptide to the walls of the pipe.