发明名称 |
composto, medicamento, composição farmacêutica, preparação farmacêutica combinada, usos de um composto e de uma preparação combinada, e, processo para a preparação de composto. |
摘要 |
The invention concerns venlafexine-N-oxide and O-desmethylvenlafaxine-N-oxide as prodrugs of venlafexine and its major (active) metabolite O-desmethylvenlafaxine respectively, to pharmaceutical compositions containing these N-oxides, to methods for preparing them, and methods for preparing compositions. The invention relates to N-oxide, having formula (1), wherein R<SP>1</SP> is H or CH3, and tautomers, stereoisomers, hydrates and solvates thereof. The invention also relates to the uses of the N-oxides and compositions, particularly for the manufacture of medicaments useful in the treatment of affections or diseases effectively treatable-albeit with side effects- with venlafexine. |
申请公布号 |
BRPI0813658(A2) |
申请公布日期 |
2016.10.18 |
申请号 |
BR2008PI13658 |
申请日期 |
2008.06.23 |
申请人 |
SOLVAY PHARMACEUTICALS B.V. |
发明人 |
AXEL STOIT;CORNELIS G. KRUSE;LECHOSLAW A. TURSKI;MARTINUS TH. M. TULP;SANDER VADER |
分类号 |
A61K31/135;A61P25/24;C07C291/04 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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