| 摘要 |
<p>The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NSl). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.</p> |
| 申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY;MONTELIONE, GAETANO;DAS, KALYAN;ARNOLD, EDWARD;MA, LICHUNG;XIAO, RONG;KRUG, ROBERT, M.;TWU, KAREN, Y.;KUO, REI-LIN |
发明人 |
MONTELIONE, GAETANO;DAS, KALYAN;ARNOLD, EDWARD;MA, LICHUNG;XIAO, RONG;KRUG, ROBERT, M.;TWU, KAREN, Y.;KUO, REI-LIN |
