| 发明名称 | Immunostimulatory combinations of TLR ligands and methods of use | ||
| 摘要 | The present invention provides immunostimulatory combinations of TLR ligands and therapeutic and/or prophylactic methods that include administering an immunostimulatory combination to a subject. In general, the immunostimulatory combinations described herein can provide an increased immune response compared to other immunostimulatory combinations and/or compositions. | ||
| 申请公布号 | US9421254(B2) | 申请公布日期 | 2016.08.23 |
| 申请号 | US200812679881 | 申请日期 | 2008.09.24 |
| 申请人 | The United States of America, as represented by the Secretary, Department of Health and Human Services | 发明人 | Berzofsky Jay A.;Zhu Qing;Belyakov Igor |
| 分类号 | A61K39/00;A61K39/38;A61K45/00;A61K51/00;A61K39/39 | 主分类号 | A61K39/00 |
| 代理机构 | Locke Lord LLP | 代理人 | Locke Lord LLP ;McCool Gabriel J. |
| 主权项 | 1. An immunostimulatory composition for inducing high functional avidity T cells comprising a combination of three or more Toll Like Receptor (TLR) agonists, said composition comprising an effective amount of MALP-2, a TLR2 agonist, polyl:C, a TLR3 agonist, and CpG, a TLR9 agonist, wherein the triple combination of TLR agonists synergistically activates IL-15 and IL-12 production of dendritic cells as compared to a double combination of TLR agonists thereby inducing high functional avidity T cells. | ||
| 地址 | Washington DC US | ||