发明名称 ネプリライシン阻害剤
摘要 In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
申请公布号 JP5944921(B2) 申请公布日期 2016.07.05
申请号 JP20130544730 申请日期 2011.12.14
申请人 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 发明人 ジェンドロン, ローランド;フルーリー, メリッサ;ヒューズ, アダム ディー.
分类号 C07D213/81;A61K31/341;A61K31/381;A61K31/41;A61K31/415;A61K31/4155;A61K31/4162;A61K31/4166;A61K31/4178;A61K31/4192;A61K31/4196;A61K31/42;A61K31/421;A61K31/422;A61K31/423;A61K31/4245;A61K31/426;A61K31/437;A61K31/4439;A61K31/454;A61K31/465;A61K31/4965;A61K31/497;A61K31/50;A61K31/505;A61K31/5365;A61K31/5377;A61K31/553;A61K45/00;A61P9/04;A61P9/12;A61P13/12;A61P43/00;C07D213/82;C07D231/14;C07D233/90;C07D237/04;C07D237/24;C07D239/28;C07D239/36;C07D241/24;C07D249/04;C07D249/10;C07D249/12;C07D249/18;C07D257/04;C07D261/18;C07D263/34;C07D263/56;C07D271/06;C07D277/56;C07D307/68;C07D333/40;C07D333/68;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/06;C07D403/12;C07D405/04;C07D405/12;C07D405/14;C07D409/04;C07D413/04;C07D471/04;C07D498/04 主分类号 C07D213/81
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