| 发明名称 | Lipid formulations | ||
| 摘要 | The invention features a cationic lipid of formula I,;an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use.;Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids. | ||
| 申请公布号 | US9394234(B2) | 申请公布日期 | 2016.07.19 |
| 申请号 | US201414319996 | 申请日期 | 2014.06.30 |
| 申请人 | Arbutus Biopharma Corporation | 发明人 | Chen Jianxin;Ansell Steven;Akinc Akin;Dorkin Joseph Robert;Qin Xiaojun;Cantley William;Manoharan Muthiah;Rajeev Kallanthottathil G.;Narayanannair Jayaprakash K.;Jayaraman Muthusamy |
| 分类号 | C07C227/00;C07B43/00;C07C227/18;A61K9/127;A61K31/22;A61K31/7088;A61K38/17;A61K38/48;C07C229/12;C07D475/04;C12N15/113;A61K47/48;A61K48/00;A61K47/14;C07C29/58;C07C227/40 | 主分类号 | C07C227/00 |
| 代理机构 | Viksnins Harris & Padys PLLP | 代理人 | Viksnins Harris & Padys PLLP |
| 主权项 | 1. A method of making a cationic lipid of formula I, or a pharmaceutically acceptable salt thereof,comprising reacting dilinoleyl methanol with dimethylaminobutyric acid, or a salt thereof, under conditions to provide the cationic lipid of formula I, or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Burnaby, BC CA | ||