Method of forming liposomes

摘要

A method of producing a liposome preparation of/encapsulating a drug or other reagent, which method comprises the steps of (i) forming empty liposomes; (ii) mixing the liposomes from step (i) with a sugar solution and a reagent; and (iii) drying the mixture from step (ii). The compositions will generally comprise less than 10 % w/v sucrose. The method can be used to form small liposomes with high entrapment efficiency (those too large for the desired purpose can be reduced by known methods such as sonication, homogenisation and others), with a reduced number of preparation steps. It is particularly useful in the production of pharmaceuticals.