发明名称 |
HUMAN ALPHA-GALACTOSIDASE VARIANTS |
摘要 |
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH <4.5) and basic (pH >7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes. |
申请公布号 |
WO2016105889(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
WO2015US63329 |
申请日期 |
2015.12.02 |
申请人 |
CODEXIS, INC. |
发明人 |
AGARD, NICHOLAS, J.;MILLER, MATHEW, G.;ZHANG, XIYUN;HUISMAN, GJALT, W. |
分类号 |
C12N15/56;A61K38/47;C07K14/47;C12N9/24 |
主分类号 |
C12N15/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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