Propofol Formulations with Non-Reactive Container Closures

摘要

A pre-filled syringe storing an anesthetic is disclosed. The pre-filled syringe includes a container configured to store a liquid anesthetic solution. The liquid anesthetic solution includes an anesthetic, water, and a solvent. The container is made of a plastic that is inert to the anesthetic. The pre-filled syringe also includes a plunger made of siliconized bromobutyl rubber that is inert to the anesthetic and a rubber stopper made of siliconized bromobutyl rubber that is inert to the anesthetic. The plunger and the rubber stopper seal the container configured to store the liquid anesthetic solution.

主权项

1. A liquid anesthetic solution stored in a container, comprising:
a container storing the liquid anesthetic solution, the container being sealed by a closure, the liquid anesthetic solution comprising: an anesthetic being from 0.1% to 10% by weight of the liquid anesthetic solution, water, and a solvent, wherein: the container comprises a material that is inert to the anesthetic, and the closure comprises siliconized rubber, a fluoropolymer, or a metal that is inert to the anesthetic, and a concentration of the anesthetic in the liquid anesthetic solution stored in the container following a predetermined time period is at least 93% of a concentration of the anesthetic in the liquid anesthetic solution before the liquid anesthetic solution is stored in the container.