| 摘要 |
A method for preparing a composition comprising topical anesthetic containing liposomes wherein the weight concentration of the topical anesthetic in said composition is greater than 10%, said method comprising: (i) providing a non-aqueous composition, said non-aqueous composition comprising: a topical anesthetic, a C14-C20 alcohol, an alkyl ester of a fatty acid, propylene glycol, and a polyalkyl stearate; (ii) providing an aqueous composition comprising water; and (iii) mixing said aqueous composition and said non-aqueous composition so as to form a liposomal structure wherein said liposomes are disposed in said aqueous composition and wherein the concentration of said anesthetic in said composition is greater than 10%.
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