METHOD FOR PRODUCING LIPOSOMAL FORMULATIONS OF ACTIVE AGENTS

摘要

The invention relates to a method for producing liposomes containing an active agent in the form of at least one physiologically effective and/or diagnostic compound by producing a mixture of membrane-forming amphiphiles, dispersing the mixture in water and homogenising the dispersion under high pressure until the liposomes are formed. The liposomal formulations are obtained by a) adjusting the mixture to produce a liposome formulation containing at least 20 wt. % lipids; b) adding the active agent to this liposome formulation and c) incubating and moving the mixture containing the active agent mechanically until at least 10 % of the liposomes contain some of the active agent, the temperature being regulated in such a way that essentially no phospholipid hydrolysis takes place but fusion is increased. The invention also relates to the liposomal formulation produced according to this method and to the use of said formulation as a diagnostic or therapeutic agent which can optionally also contain other auxiliary and support substances and/or stabilisers.