发明名称 |
Cancer targeting peptides for enhancing anti-cancer drug delivery and therapeutic efficiencies |
摘要 |
A peptide targeted conjugate is disclosed. The conjugate comprises: (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1, 2 and 3; and (b) a component, to which the targeting peptide is conjugated, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, liposomes, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. The conjugate may further comprise an anti-cancer agent encapsulated within the drug delivery vehicle. Compositions and methods of treating cancer are also disclosed. |
申请公布号 |
US9393316(B2) |
申请公布日期 |
2016.07.19 |
申请号 |
US201414499201 |
申请日期 |
2014.09.28 |
申请人 |
ACADEMIA SINICA |
发明人 |
Wu Han-Chung;Wu Chien-Hsun |
分类号 |
A61K31/437;A61K31/704;A61K47/48;C07K7/08 |
主分类号 |
A61K31/437 |
代理机构 |
Intellectual Property Connections, Inc. |
代理人 |
Saunders Hsiu-Ming;Intellectual Property Connections, Inc. |
主权项 |
1. A conjugate comprising:
(a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 2 and 3; and (b) a component, to which the targeting peptide is conjugated, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, liposomes, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. |
地址 |
Taipei TW |