Use of derivatives containing C—O—P bonds in patients with kidney failure

摘要

Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimirnetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.

主权项

1. A method for the treatment and/or inhibition of a kidney failure-related disease comprising administering to a subject with kidney failure an effective amount of a medicament which comprises at least one compound of formula I, or a pharmaceutically acceptable salt thereof:where:
R1 R3, R5, R7, R9, and R11 independently represent H or a compound of formula II: R13 represents H; R2, R4, R6, R8, R10 and R12 represent H; and wherein at least one of the radicals R1, R3, R5, R7, R9 and R11 represents a compound of formula II, characterised in that said medicament is administered in a non bolus prolonged release form, and wherein the medicament is found in a form suitable for parenteral, topical or enteral administration.