发明名称 PROCESS FOR SYNTHESIS OF A TEMPERATURE- AND PH-SENSITIVE HYDROGEL
摘要 The invention relates to a process for the synthesis of a polymeric hydrogel to prepare multi-membrane systems to be used as matrices for embedding controlled-release bioactive substances. According to the invention, the process comprises the reticulation of a copolymer based on a methacrylic monomer and a spiro-orthoester, using an amide monomer as a reticulation agent, in the presence of a radical initiator, sodium persulphate, and a reaction accelerator (N, N, N', N'-tetramethyl ethylenediamine) in dimethyl acetamide.
申请公布号 RO128903(B1) 申请公布日期 2016.11.29
申请号 RO20120000779 申请日期 2012.11.01
申请人 ACADEMIA ROMÂNĂ - INSTITUTUL DE CHIMIE MACROMOLECULARĂ "PETRU PONI" IAŞI 发明人 CHIRIAC AURICA;NIŢĂ LOREDANA ELENA;NEAMŢU IORDANA;NISTOR MANUELA TATIANA
分类号 A61K9/26 主分类号 A61K9/26
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