发明名称 |
COMPOSITIONS AND METHODS FOR THERAPY OF PROSTATE CANCER USING DRUG COMBINATIONS TO TARGET POLYAMINE BIOSYNTHESIS AND RELATED PATHWAYS |
摘要 |
Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that contains i) an inhibitor of methionine salvage pathway in prostate of the individual and ii) a polyamine analogue. The methods are for use in individuals who have been diagnosed with, or are suspected of having or at risk for developing androgen sensitive prostate cancer (AS-CaP), or Castration recurrent CaP (CR-CaP), or benign prostate hyperplasia (BPH). The disclosure includes use of inhibitors of methylthioadenosine phosphorylase (MTAP), and a polyamine analog that upregulates polyamine catabolism by increasing spermidine/spermine Nl -acetyl transferase (SAT1) activity, such as methylthio-DADMe-Immucillin (MTDIA), andl),N(11)-bisethylnorspermine (BENSpm), respectively. Pharmaceutical formulations that contain a combination of the inhibitor of the methionine salvage pathway and a polyamine analogue are included, as are kits that contain such agents. |
申请公布号 |
WO2016187183(A1) |
申请公布日期 |
2016.11.24 |
申请号 |
WO2016US32838 |
申请日期 |
2016.05.17 |
申请人 |
HEALTH RESEARCH, INC.;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
SMIRAGLIA, Dominic;AFFRONTI, Haley;CASERO, Robert |
分类号 |
A61K38/43;A61K38/16;A61K38/45 |
主分类号 |
A61K38/43 |
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