CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY

摘要

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

主权项

1. A method to enhance the population of progenitor and/or stem cells in a subject, the method comprising:
administering to said subject a compound of the formulaor the salts or pro-drug forms thereof; and including any stereoisomeric forms thereof wherein:
X and Y are independently N or CR1; Z is S, O, NR1, or CR12; each R1-R6 is independently H or a noninterfering substituent; n1 is 0-4; n2 is 0-1, wherein the * signifies C≡C may be substituted for CR5═CR5; n3 is 0-4; wherein n1+n2+n3 is greater than or equal to 2; b is 0-2; wherein the following combinations of R groups may be coupled to generate a ring, which ring may be saturated or unsaturated: R2+R2, one R2+R3, R3+one R4, R4+R4, one R5+another R5, one R5+one R6, and R6+R6; wherein the ring may not be aromatic when the participants in ring formation are two R5; and wherein when n2 is 1, neither n1 nor n3 can be 0; in an amount effective to elevate said progenitor and/or stem cell population in said subject.