Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications

摘要

The disclosure generally relates to a particulate composition formed from a conductive polymer (e.g., conductive polyanilines, polypyrroles, polythiophenes) bound to magnetic nanoparticles (e.g., Fe(II)- and/or Fe(III)-based magnetic metal oxides). The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody) bound to the conductive polymer of the particulate composition. Methods and kits employing the particulate composition and the BEAM nanoparticle composition also are disclosed.

主权项

1. A biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition comprising:
(a) a particulate composition comprising a conductive polymer bound to magnetic nanoparticles; and, (b) a binding pair member bound to the conductive polymer of the particulate composition; wherein:
the binding pair member is complementary to a target analyte,the particulate composition ranges in size from about 1 nm to about 500 nm, andthe weight ratio of conductive polymer to magnetic nanoparticles in the particulate composition ranges from about 0.1 to about 1.