Novel gamma-butyrolactone derivatives.

摘要

Novel gamma -butyrolactone derivatives having strong ACE inhibitory activity are provided. They are represented by the following general formula (I): <CHEM> wherein R<1> and R<2> may be the same or different and mean individually a hydrogen atom or a straight-chain or branched alkyl or cycloalkyl group, or R<1> and R<2> are bonded together to mean an alkylene group having 2 - 6 carbon atoms, R<3> denotes a hydrogen atom or a lower alkyl, aralkyl, amino lower alkyl or lower alkoxycarbonylamino lower alkyl group, R<4> means a lower alkyl, cycloalkyl or aralkyl group, R<5> means a hydrogen atom or a lower alkyl group, or R<4> and R<5> are bonded together to denote an alkylene group having 2 - 4 atoms, and R<6> stands for a hydrogen atom or a lower alkyl or aralkyl group; or a pharmacologically acceptable salt thereof.