| 摘要 |
<p>PCT No. PCT/EP94/01035 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Apr. 2, 1994 PCT Pub. No. WO94/24093 PCT Pub. Date Oct. 27, 1994.Compounds of formula (I): H2N-(CH2)n-A-(CH2)m-O-NH2 and salts thereof are described in which the radical A is C3-C6 cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the aminooxy radical H2N-O- and the amino group -NH2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H2N-(CH2)n- and -(CH2)m-O-NH2 are not bonded to the same ring carbon of A. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.</p> |
