| 摘要 |
PURPOSE:To obtain the subject medicinal composition useful as a prophylactic or therapentic medicine for Pneumocytis carini pneumonia having an antifungal action by using a solubilzing agent for Aculeacin, containing glycyrrhizin as an active ingredient and an Aculeacin. CONSTITUTION:The objective composition comprising a freeze-dried preparation which is dissolved in water on use and having antifungal activity is obtained by adding germ-free distilled water to a solubilizing agent for Aculeacin, containing glycyrrhizin such as dipotassium glycyrrhizinate as an active ingredient, and an Aculeacin such as Aculeacin Agamma, treating the solution with ultrasonic waves for 10 minutes to accelerate solubilization into a clear solution, subjecting the solution to aseptic filtration through a 0.22mum membrane filter, fractionating the filtrate into vials 1ml each and freeze-drying them. Further, when sodium salycilate or sodium benzoate is added to the composition, the solubility of the Aculeacin can be increased to give turbid-free preparations even when amino acids are further added and the mixed solution is admixed to infusion liquid. |
