| 发明名称 | Compositions of hyaluronan with high elasticity and uses thereof | ||
| 摘要 | The present invention provides compositions comprising hyaluronan with high elasticity, as well as methods for improving joint function, reducing pain associated with joint function and treating osteoarthritis by introducing into a joint a therapeutically effective amount of a composition comprising hyaluronan with high elasticity. | ||
| 申请公布号 | US9492474(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201414327321 | 申请日期 | 2014.07.09 |
| 申请人 | Matrix Biology Institute | 发明人 | Balazs Endre A.;Belmonte Carlos |
| 分类号 | A61K31/728;C08B37/08;A61K9/00 | 主分类号 | A61K31/728 |
| 代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Zacharakis Maria Laccotripe |
| 主权项 | 1. A high elasticity composition suitable for intra-articular injection comprising hyaluronan, wherein: the hyaluronan is present in said composition at a concentration of greater than 30 mg/mL; the hyaluronan has an average molecular weight of between 1.3 and 2 million; the hyaluronan is not cross-linked and/or is substantially free of chemical modifications; wherein the composition is substantially free of a pharmaceutically active substance selected from the group consisting of a protein, a glycosaminoglycan that is different from hyaluronan, hydroxypropyl methyl cellulose and a local anesthetic; wherein the composition is sterile; and wherein the composition has an elasticity (G′) of at least 900 Pascal when measured at a frequency of 5.0 Hz. | ||
| 地址 | Edgewater NJ US | ||