Methods for making biocompatible polymerizable acrylate products

摘要

Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form polymers, adhesives, hydrogels, and the like. The sugar-acrylic monomers and polymers may be used in tissue engineering, adhesives and sealers, wound healing, and the like.

主权项

1. A method for making a biocompatible polymerizable acrylate product, the method comprising:
providing a carbohydrate having a plurality of hydroxyl groups; contacting the carbohydrate with a protecting group agent to yield a protected carbohydrate; linking a polymerizable acrylate group to the protected carbohydrate to yield a polymerizable acrylate monomer having a pendant carbohydrate moiety, wherein the step of linking the polymerizable acrylate group to the protected carbohydrate includes bonding a cyanoacrylate intermediate group to the protected carbohydrate and then converting the cyanoacrylate intermediate group to a polymerizable cyanoacrylate; and placing the polymerizable acrylate monomer in a water-tight sealed packaging, the sealed packaging being configured to have the seal broken when it is desired to use the polymerizable acrylate monomer.