Compounds capable of inhibiting voltage gated calcium ion channel, and pharmaceutical compositions comprising the same

摘要

Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect.

主权项

1. A compound selected from the group consisting of a N-(pyrazolylmethyl)arylsulfonamide derivative represented by the following Chemical Formula 1, and a pharmaceutically acceptable salt thereof: wherein, X is wherein R1 represents C6˜C12 aryl, substituted with one to three substituents selected from the group consisting of halo, C1˜C6 alkyl and piperidin-1-yl, or unsubstituted; or 5- to 12-membered heteroaryl with 1 to 3 nitrogen atoms, R2 represents a hydrogen atom; or C1˜C6 alkyl, R3 represents a hydrogen atom; or C1˜C6 alkyl, R4 and R5 independently represent C1˜C6 alkyl; or phenyl, substituted with a substituent selected from the group consisting of halo, C1˜C6 alkyl, C1˜C6 haloalkyl, and piperidin-1-yl, or unsubstituted, with the proviso that any one of R4 and R5 is substituted or unsubstituted phenyl while the other represents C1˜C6 alkyl, and n is an integer of 0 to 6.