METHODS FOR TREATING CANCER IN PATIENTS WITH ELEVATED LEVELS OF BIM

摘要

Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD 1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.

主权项

1. A method for treating a mammal having cancer, wherein said method comprises:
(a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, a fusion protein comprising a portion of PD-1 linked to an immunoglobulin Fc sequence, or a fusion protein comprising a portion of CD80 linked to an Ig Fc sequence, under conditions wherein the interaction of naturally-occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.