发明名称 MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS
摘要 PROBLEM TO BE SOLVED: To provide a novel hepatitis C virus (HCV) protease inhibitor compound, to provide a method for treating HCV infection using them, and to provide a method for producing such a compound.SOLUTION: The present invention discloses compounds represented by formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof. The compounds represented by the formula (I) inhibit serine protease activity, particularly, the activity of hepatitis C virus (HCV) NS3-NS4A protease.EFFECT: The compounds interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention relates to a pharmaceutical composition containing the aforementioned compounds for administration to a subject suffering from HCV infection, and the pharmaceutical composition is used in the treatment of HCV infection in the subject by administering a pharmaceutical composition comprising the compounds.SELECTED DRAWING: None
申请公布号 JP2016104756(A) 申请公布日期 2016.06.09
申请号 JP20150241811 申请日期 2015.12.11
申请人 ENANTA PHARMACEUTICALS INC 发明人 OR YAT SUN;MA JUN;WANG GUOQIANG;LONG JIANG;WANG BING
分类号 C07K5/08;A61K31/13;A61K31/7056;A61K38/00;A61K38/21;A61K45/00;A61P31/12;A61P31/14;A61P43/00 主分类号 C07K5/08
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