| 主权项 |
1. A compound of formula I or an enantiomer, diastereomer, tautomer, or salt thereof wherein: X is H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, 4- to 12-membered heterocyclyl, —CN, —NO2, —SO2NR11R12, —CONR11R12, —NR11CONR11R12, —NCOR11, —CO2R11or —NR11R12; Y is H, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, 4- to 12-membered heterocyclyl, —CN, —NO2, —SO2NR11R12, —CONR11R12, —NR11CONR11R12, —NCOR11, —CO2R11 or—NR11R12; Z is H, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-10 cycloalkyl, a 6- to 12-membered heteroaryl, 4- to 12-membered heterocyclyl, —NO2, —SO2NR11R12, —NCOR11, —NR11SO2NR11R12, —OCONR11R12, or —NR11R12; A is —(CH2)m—R2, —CH(R25)(R26), or —CH(R26)—CO2—R2a ; m is 0 to 4; n is 1 to 4; R1 is —OH, F, Cl, Br, I, C1-10 alkyl, haloC1-10 alkyl, C2-12 alkenyl, C3-10 cycloalkyl, —CN, —(CH2)n—SO2NR11R12,or —(CH2)n—NR11SO2R12, wherein the alkenyl and cycloalkyl may be optionally substituted with one or more R13's; or R1 is selected from the group consisting of: R1 is R2 is C1-10 alkyl, cyclopropyl optionally substituted with one or more R13's; C4-10 cycloalkyl optionally substituted with one or more R13bb's; or —NR14R14; provided that R2 is not —NR14R14 when m is 0, 1 or 3; or R2 is or R2 is selected from the group consisting of: R2a is C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, —NR14R14, a 4- to 12-membered heteroaryl or 4- to 12-membered heterocyclyl, any of which is optionally substituted with one or more R13's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R11 and R12, at each occurrence, are independently selected from H, C1-10 alkyl, haloC1-10 alkyl, C3-10 cycloalkyl, C6-10aryl, a 4- to 12-membered heteroaryl and a 4- to 12-membered heterocyclyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R13's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; or R11 and R12 are taken together with the nitrogen to which they are attached to form a 4- to 12-membered heterocyclyl, wherein the heterocyclyl may be optionally substituted with one or more R13's and the heterocyclyl consists of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or CONR14OR14 , wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; provided that when R13 is alkyl substituted with one R14a, R14a is not —OH; R13a, at each occurrence, is independently H, —OH, F, Cl, Br, I, C2-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13aa, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13a-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13a-2, at each occurrence, is independently H, —OH, F, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, or —CONR14OR14 wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13a-4, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13b, at each occurrence, is independently H, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13bb, at each occurrence, is independently H, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14 —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, or —CONR 14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13b-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14R14, —CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13b-2, at each occurrence, is independently H, —OH, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC2-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13b-4, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14,or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13b-5, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14R 14,CONR1414OR14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13c, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —NR14CO2R14, —CO2R26, —NR14R14, —NR14CONR14R14 , —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13cc, at each occurrence, is independently H, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13c-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC2-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 6- to 12-membered heteroaryl, a 6- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —NO2, —NR14SO2R14, ═O, —(CH2)m—NR14SO2R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13c-2, at each occurrence, is independently H, —OH, F, Cl, Br, I, C2-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, or —CONR14OR14wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13c-4, at each occurrence, is independently H, —OH, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14,or —CONR14OR14 wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13c-5, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13d, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C2-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14 wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13dd, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13d-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC2-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14CONR14R14, or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13d-2, at each occurrence, is independently H, —OH, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13d-4, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, or —CONR14OR14 wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13e, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or—CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13ee, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13e-1, at each occurrence, is independently H, —OH, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC2-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14 , wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13e-2, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14 or —CONR14OR14 wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13f, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C2-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13g, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14 wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13g-2, at each occurrence, is independently H, —OH, F, Cl, Br, I, C2-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14 , wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13h, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13h-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C7-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13hh, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl,. heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13hh-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C2-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13hh-2, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13j, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13m, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13m-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13n-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C2-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13p, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14,wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13p-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14, NR14R14, —CONR14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13p-2, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13q, at each occurrence, is independently H, —OH, F, Cl, Br, I, C2-10 alkyl, C1-10 alkoxy, haloC2-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13q-1, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, ═O, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or —CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R13q-2, at each occurrence, is independently H, —OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, haloC1-10 alkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-C1-10 alkyl, —CN, —NO2, —(CH2)m—SO2R14, —NR14SO2R14, —CONR14R14, —(CH2)m—SO2NR14R14, —(CH2)m—NR14SO2R14, —(CH2)n—NR14SO2NR14R14, —NR14SO2NR14R14, —CO2NR14R14, —NR14CO2NR14R14, —NR14COR14, —SO2NR14COR14, —SO2NR14CONR14R14, —NR14CO2R14, —CO2R14, —NR14R14, —NR14CONR14R14 or CONR14OR14, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R14, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4- to 12-membered heteroaryl or a 4- to 12-membered heterocyclyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with be optionally substituted with 0-3 R14a and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; or two R14's are taken together with the atoms to which they are attached to form a cyclic ring, wherein the cyclic ring may be optionally substituted with one or more R24a's and optionally contain 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R14a, at each occurrence, is independently selected from F, Cl, Br, I, C1-10 alkyl, haloC1-10 alkyl, C6-10 aryl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, F, Cl, Br, I, —CN, —NO2, —CO2R26, —OCONR24R24, —OCF3, —OR25, —CONR24R24, —COR24, —SO2R24, —NR24R24, —NR24CO2R24, —SO2NR24R24, or C6-10arylC1-10 alkyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R24, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4- to 12-membered heteroaryl or 4- to 12-membered heterocyclyl, wherein the alkyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R24a's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; or two R24's are taken together with the atoms to which they are attached to form a cyclic ring, wherein the cyclic ring may be optionally substituted with one or more R24a's and optionally contain 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R24a, at each occurrence, is independently selected from F, Cl, Br, I, C1-10 alkyl, haloC1-10 alkyl, C6-10 aryl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, —CN, —NO2, —CO2R25, —OCF3, —OR25, —CONR25R25, —COR25, —NR25R25, —NR25CO2R25, or C6-10 arylC1-10 alkyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R24b, at each occurrence, is independently selected from C1-10 alkyl, C6-10 aryl, C3-10 cycloalkyl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, —CO2R25, —SO2NR25R25 or C6-10 arylC1-10 alkyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; R25, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4- to 12-membered heteroaryl or 4- to 12-membered heterocyclyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; and R26, at each occurrence, is independently selected from C1-10alkyl, haloC1-10 alkyl, C3-10 cycloalkyl, C6-10 aryl, a 4- to 12-membered heteroaryl or 4- to 12-membered heterocyclyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O; provide thatcompound is no a compound formula Ib or Ic |
