Combination therapy for treating hearing and balance disorders

摘要

The present application relates to combinations of inhibitors directed at down-regulation of genes associated with hearing loss including HES1, HES5, HEY2, CDKN1B and NOTCH1, exhibiting a beneficial effect and useful in treating or attenuating hearing loss, treating balance impairment, promoting the replacement, regeneration, or protection of otic (sensory) hair cells of the inner ear, and or effecting hearing restoration/regeneration.

主权项

1. A method of preventing, treating or delaying the progression of a hearing disorder, a hearing loss and/or a balance impairment in a subject, or preventing the loss of otic (sensory) hair cells of the inner ear in a subject comprising administering to the subject
(i) a combination of a HES1 (SEQ ID NO:1) inhibitor, a HES5 (SEQ ID NO:2) inhibitor and a HEY2 (SEQ ID NO:10) inhibitor; or (ii) a combination of a CDKN1B (SEQ ID NO:7) inhibitor, a NOTCH1 (SEQ ID NO:11) inhibitor and a HEY2 (SEQ ID NO:10) inhibitor, wherein the inhibitors are double stranded oligonucleotides.