发明名称 |
Methods of treating a tauopathy |
摘要 |
The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods. |
申请公布号 |
US9447180(B2) |
申请公布日期 |
2016.09.20 |
申请号 |
US201514705615 |
申请日期 |
2015.05.06 |
申请人 |
iPierian, Inc. |
发明人 |
Griswold-Prenner Irene;Stagliano Nancy E.;Dang Vu Cao |
分类号 |
C07K16/18;G01N33/68;A61K39/00;C07H21/04 |
主分类号 |
C07K16/18 |
代理机构 |
Nelson Mullins Riley & Scarborough LLP |
代理人 |
Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Sloper, Esq. Jill Gorny |
主权项 |
1. An isolated nucleic acid comprising a nucleotide sequence encoding light chain variable region complementarity-determining regions (CDRs) 1, 2, and 3 of a humanized antibody that specifically binds an epitope within the N-terminal portion of a human Tau polypeptide, wherein the:
(i) VLCDR1 comprises the amino acid sequence of SEQ ID NO:1; (ii) VLCDR2 comprises the amino acid sequence of SEQ ID NO:2; and (iii) VLCDR3 comprises the amino acid sequence of SEQ ID NO:3. |
地址 |
South San Francisco CA US |