摘要 |
PROBLEM TO BE SOLVED: To provide arginase enzyme inhibitors for treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal.SOLUTION: An inhibitor comprises a composition comprising an alpha-amino acid compound, or a derivative thereof, or a salt thereof, wherein a first substituent and a second substituent are linked to the alpha-carbon of the compound. The first substituent comprises a moiety selected from the group consisting of a boronic acid and N-hydroxy guanidine. The second substituent comprises a proximal nitrogen atom, wherein: the proximal nitrogen is basic; and the proximal nitrogen is separated from the alpha-carbon by a chain of two, three or four carbons, with the proviso that the compound is not 2-amino-6-borono-2-(3-(piperazin-1-yl)propyl)hexanoic acid, 2-(3-(4-acetylpiperazin- 1-yl)propyl)-2-amino-6-boronohexanoic acid, and the like.SELECTED DRAWING: Figure 4 |