HETEROCYCLIC COMPOUND

摘要

The present invention provides a heterocyclic compound having an RORγt inhibitory action.;The present invention relates to a compound represented by the formula (I):;;wherein

Ar is a the partial structure (1) to the partial structure (5),

Q is a bivalent group selected from the group consisting of (Ia)-(If), and

B is a ring optionally having substituent(s),

or a salt thereof.

主权项

1. A compound represented by the formula (I): wherein Ar is the partial structure (1): wherein in the partial structure (1),Z is a carbonyl group or a methylene group,R1 is a C2-12 alkyl group, a substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group, an optionally substituted C7-16 aralkyl group, an acyl group or a cyano group (excluding a C1-12 alkyl group, a C2-12 alkenyl group or a C2-12 alkynyl group, each substituted by optionally substituted R2 is an optionally substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group, an optionally substituted C7-16 aralkyl group, an acyl group or a cyano group, andD1 is an optionally further substituted 6-membered aromatic ring,the partial structure (2): wherein in the partial structure (2),R3 is a C2-12 alkyl group, a substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group, an optionally substituted C7-16 aralkyl group, an acyl group or a cyano group,Y is an optionally substituted methylene group,R4 is a C2-12 alkyl group, a substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group, an optionally substituted C7-16 aralkyl group or an acyl group,R5 is a hydrogen atom or a substituent, orR4 and R5 are both methyl groups, orR4 and R5 in combination optionally form, together with the carbon atom which they are bonded to, an optionally substituted ring, andD2 is an optionally further substituted 6-membered aromatic ring, the partial structure (3): wherein in the partial structure (3),R6 is a C2-12 alkyl group, a substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group or an optionally substituted C7-16 aralkyl group, andR7 is an optionally substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group or an optionally substituted C7-16 aralkyl group, the partial structure (4): wherein in the partial structure (4),R8 and R9 are each a hydrogen atom, a C2-12 alkyl group, a substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group, an optionally substituted C7-16 aralkyl group, an acyl group or a cyano group, orR8 and R9 in combination optionally form, together with the carbon atom which they are bonded to, an optionally substituted ring, andR10 is an optionally substituted C1-12 alkyl group, an optionally substituted C2-12 alkenyl group, an optionally substituted C2-12 alkynyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C3-12 cycloalkenyl group, an optionally substituted C6-14 aryl group, an optionally substituted C7-16 aralkyl group, an acyl group or a cyano group, or the partial structure (5): wherein in the partial structure (5),R11, R12 and R13 are each a substituent, Q is a bivalent group selected from the group consisting of the following (Ia)-(Ie): wherein[A] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group, an optionally substituted C1-6 alkyl group and a C6-14 aryl group, and B is an optionally substituted ring, or a salt thereof.