发明名称 |
METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS BY STIMULATING ER STRESS |
摘要 |
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.
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申请公布号 |
US2009062227(A1) |
申请公布日期 |
2009.03.05 |
申请号 |
US20080056192 |
申请日期 |
2008.03.26 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
SCHONTHAL AXEL H.;PETASIS NICOS A.;HOFMAN FLORENCE M.;LOUIE STAN G.;CHEN THOMAS C. |
分类号 |
A61K31/415;A61K31/427;A61K31/4418;A61K31/472;A61K31/496;A61K31/69;A61K31/7105;A61P35/00;C40B30/00 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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