发明名称 |
α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
摘要 |
The invention provides α-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1′-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment. |
申请公布号 |
US9447055(B1) |
申请公布日期 |
2016.09.20 |
申请号 |
US201614987586 |
申请日期 |
2016.01.04 |
申请人 |
Merck Serono S.A. |
发明人 |
Page Patrick Naxos;Schwarz Matthias;Jorand-Lebrun Catherine;Quattropani Anna;Pomel Vincent |
分类号 |
C07D277/06 |
主分类号 |
C07D277/06 |
代理机构 |
Clark & Elbing LLP |
代理人 |
Clark & Elbing LLP ;Bieker-Brady Kristina |
主权项 |
1. A compound represented by formula (III) |
地址 |
Coinsins CH |