METHODS AND COMPOSITIONS FOR MODULATING CELL DEATH WITH SURVIVAL-OR DEATH KINASES OR PHOSPHATASES

摘要

The invention relates to methods for modulating cell death and cell survival and for modulating the sensitivity of cells towards agents that modulate cell death or cell survival. The invention also relates to the identification of kinases and phosphatases that promote cell survival or cell death. The invention further relates to methods for screening compounds that modulate the activity, expression and/or protein-protein interactions of cell survival or cell death-promoting kinases and phosphatases. Accordingly, kinases and/or phosphatases that modulate cell proliferation and death may serve as therapeutic targets for the development of new cancer treatments.