Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators

摘要

Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.

主权项

1. A composition comprising:
a polymeric chelator comprising a plurality of polyamine polymer backbone chains and one or more chelators, wherein the polyamine polymer backbone chains are polyallylamine or polylysine; wherein the one or more chelators are covalently coupled to one or more primary amines, respectively, of at least one of the plurality of polyamine polymer backbone chains through one or more amide bonds, respectively, wherein each of the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free; and wherein the plurality of polyamine polymer backbone chains are cross-linked to one another independent of any cross-linking that may result from interactions with the one or more chelators.