Methods and compositions for reducing Shiga toxin induced toxicity in mammals

摘要

Manganese compositions effective in reducing Shiga toxin-induced toxicity in mammals infected with Shiga toxin-producing bacteria such as E. coli O157:H7 are described. Manganese compositions described herein can be combined with antibiotic therapy as manganese can block the toxic effects of Shiga toxin released from dying bacteria.

主权项

1. A method of reducing Shiga toxin (STx)-induced toxicity in a mammal infected with STx-producing bacteria, said method comprising administering to said infected mammal a manganese composition comprising from about 0.002 mg/kg of body weight to about 50 mg/kg of body weight of manganese.