MATRIX MATALLOPROTEASE INHIBITORS

摘要

Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R<1> is hydrogen or lower alkyl; R<2> is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heteroarylheteroalkyl, heterocyclo, heterocylo-lower alkyl, heterocyclo-lower heteroalkyl or -NR<6>R<7>, wherein: R<6> is hydrogen, lower alkyl, cycloalkyl or cycloalkylalkyl, aryl, heteroaryl and heteroaralkyl; R<7> is hydrogen, lower alkyl, cycloalkyl or cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, -C(O)R<8>, -C(O)NR<8>R<9>, -SO2NR<8>R<9>, -SO2R<10>, aryloxycarbonyl, or alkoxycarbonyl; or R<6> and R<7> together with the nitrogen atom to which they are attached represent a heterocyclo group; wherein R<8> and R<9> are independently hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or heteroalkyl; and R<10> is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl or heterocyclo; or R<1> and R<2> together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclo group; R<3> is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl or lower alkoxy; R<4> is hydrogen, lower alkyl, cycloalkyl or cycloalkylalkyl; or R<2> and R<3> together with the carbons to which they are attached represent a cycloalkyl or heterocyclo group; or R<3> and R<4> together with the carbon to which they are attached represent a cycloalkyl or heterocyclo group; and R<5> is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or pharmaceutically acceptable salts or esters thereof exhibit useful pharmacological properties, in particular for use as matrix metalloprotease inhibitors, particularly for interstitial collagenases.