Composition for inducing proliferation or accumulation of regulatory T cells

摘要

It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

主权项

1. A method of treating a human subject having an infectious disease, an autoimmune disease, or an allergic disease, the method comprising administering a pharmaceutical composition comprising a purified bacterial mixture of at least two live bacterial strains belonging to Clostridium clusters IV and/or XIVa to the human subject, wherein the bacterial strains are spore-forming bacteria and are isolated from a human.