Preparing composition containing e.g. rifampicin, and optionally ethambutol, comprises wet granulation of isoniazid, pyrazinamide and optionally ethambutol by wetting with binder in solvent, drying and adding rifampicin

摘要

Preparing a pharmaceutical composition containing in combination with rifampicin, isoniazid, and pyrazinamide, and optionally ethambutol or its salt, comprises: wet granulation of isoniazid, pyrazinamide and optionally ethambutol by wetting with at least one binder dissolved in a volatile organic solvent, to obtain grains; drying the grain; and adding rifampicin. ACTIVITY : Antitubercular; Tuberculostatic. MECHANISM OF ACTION : None given.