发明名称 |
Biodegradable polymer matrices for sustained delivery of local anesthetic agents |
摘要 |
<p>An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation. <IMAGE> <IMAGE></p> |
申请公布号 |
EP1132080(A2) |
申请公布日期 |
2001.09.12 |
申请号 |
EP20010201822 |
申请日期 |
1993.09.10 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
BERDE, CHARLES B.;LANGER, ROBERT S. |
分类号 |
A61K9/00;A61K9/16;A61K9/20;A61K9/22;A61K9/52;A61K31/165;A61K31/167;A61K31/245;A61K31/445;A61K31/47;A61K47/34;A61P25/02;(IPC1-7):A61K9/20 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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