Notch-binding agents and antagonists and methods of use thereof
摘要
NOTCH-BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
申请公布号
AU2016216568(A1)
申请公布日期
2016.09.01
申请号
AU20160216568
申请日期
2016.08.16
申请人
ONCOMED PHARMACEUTICALS, INC.
发明人
SATO, AARON KEN;GURNEY, AUSTIN L.;HTUN VAN DER HORST, EDWARD THEIN;LIU, YUAN CHING;BRUHNS, MAUREEN FITCH;HOEY, TIMOTHY CHARLES;LEWICKI, JOHN A.