| 主权项 |
1. A method for the diagnosis, follow-up, or treatment of a cancer disease in a subject comprising: administering to the subject a recombinant recognition molecule which comprises a variable heavy chain and a variable light chain and which specifically binds to core 1 antigen, wherein
the variable heavy chain comprises (i) a CDRH1 region that comprises the amino acid sequence of SEQ ID NO: 1, or a variant thereof having at least 70% homology with SEQ ID NO: 1; (ii) a CDRH2 region that comprises the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 3, or a variant thereof having at least 70% homology to SEQ ID NO: 2 or SEQ ID NO: 3; and (iii) a CDRH3 region that comprises the amino acid sequence of SEQ ID NO: 4, SEQ ID NO: 5, or SEQ ID NO: 6, or a variant thereof having at least 70% homology to SEQ ID NO: 4, SEQ ID NO: 5, or SEQ ID NO: 6; and the variable light chain comprises (i) a CDRL1 region that comprises the amino acid sequence of SEQ ID NO: 7, SEQ ID NO: 8, or SEQ ID NO: 9, or a variant thereof having at least 70% homology to SEQ ID NO: 7, SEQ ID NO: 8, or SEQ ID NO: 9; (ii) a CDRL2 region that comprises the amino acid sequence of SEQ ID NO: 10 or SEQ ID NO: 11, or a variant thereof having at least 70% homology to SEQ ID NO: 10 or SEQ ID NO: 11; and a CDRL3 region that comprises the amino acid sequence of SEQ ID NO: 12 or SEQ ID NO: 13, or a variant thereof having at least 70% homology to SEQ ID NO: 12 or SEQ ID NO: 13. |
