Pyrrolidine carboxylic acid derivatives, pharmaceutical composition and methods for use in treating metabolic disorders as agonists of G-Protein Coupled Receptor 43 (GPR43)

摘要

The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases. Figure I 1h0I 35 Compun~d 2 MUM compound 1 OKImoud Smt .. mun 4... U z VV "peQ~." Of Miae1 ~t -"a R3- -R 4' Ar -L1 L3-Z 'L2, L 2-Ar 2 6484816 1 (GHMatters) P90475.AU.1 JENNYP Figure 1 - Vehicle c 0 .. Compound 2 a100 E Compound 1 90- A Compound 111 Lu _T Compound 8 a Compound 10 0 Compound 4 70- -- ---0su Compound 113 Compound 5 Statistics: One-Way ANOVA and Dunneis post-oc *'<001 treated vs vehicle