| 发明名称 |
Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 |
| 摘要 |
Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein. |
| 申请公布号 |
US8623885(B2) |
申请公布日期 |
2014.01.07 |
| 申请号 |
US201213425817 |
申请日期 |
2012.03.21 |
| 申请人 |
CHEN XIAOQI;DAI KANG;DUQUETTE JASON;GRIBBLE, JR. MICHAEL W.;HUARD JUSTIN N.;KEEGAN KATHLEEN S.;LI ZHIHONG;LIVELY SARAH E.;MCGEE LAWRENCE R.;RAGAINS MARK L.;WANG XIANGHONG;WEIDNER MARGARET F.;ZHANG JIAN;AMGEN INC. |
发明人 |
CHEN XIAOQI;DAI KANG;DUQUETTE JASON;GRIBBLE, JR. MICHAEL W.;HUARD JUSTIN N.;KEEGAN KATHLEEN S.;LI ZHIHONG;LIVELY SARAH E.;MCGEE LAWRENCE R.;RAGAINS MARK L.;WANG XIANGHONG;WEIDNER MARGARET F.;ZHANG JIAN |
| 分类号 |
A61K31/505;C07D487/12 |
主分类号 |
A61K31/505 |
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