| 摘要 |
The invention comprises a solid phase pharmaceutical composition of a drug that tastes bitter when it is at its drug-pH, wherein the solid phase pharmaceutical composition comprises the drug the drug-pH of which is modified to a different pH to render it bitter-less or to render its bitterness substantially reduced to make its oral consumption bearable; the pH modified drug being obtained by exposing the drug to a pH modifier under conditions required for modifying the drug-pH to the different pH, and thereafter solidifying the composition containing the pH modified drug; the "drug-pH" being defined as the pH of water when the active form of the water soluble or partly soluble drug is, respectively, dissolved or partly dissolved in water. The solid phase pharmaceutical composition described above may be in the form of tablets, powder, granules or pellets; which are consumed orally as solids or after constituting in a suspension by adding water. |
