| 摘要 |
The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and me thods to use them to treat mammals suffering from various conditions related to the pharmacologic activities. Modifications of the cupredoxin derived pe ptides include amino acid sequence variants and structural derivations that increase the plasma half-life of the peptide, increase the specific activity of the pharmacologic activity, decrease immunogenicity, and decrease the bi otransformation of the peptides. The modified cupredoxin derived peptides ca n be used in methods to treat mammals for cancer, conditions related to inap propriate angiogenesis,, viral and bacterial infections, and specifically HI V and malaria, conditions related to ephrin signaling, and to deliver cargo compounds, including diagnostic compounds, to cancer cells.
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