| 摘要 |
The present invention relates to a recombinant binding protein comprising at least one derivative of the Src homology 3 domain (SH3) of the FYN kinas e, wherein at least one amino acid in or positioned up to two amino acids ad jacent to the src loop and/or at least one amino acid in or positioned up to two amino acids adjacent to the RT loop is substituted, deleted or added. F urthermore, the invention is directed to fusion proteins comprising a bindin g protein according to the invention fused to a pharmaceutically and/or diag nostically active component. In addition, the invention concerns nucleotides coding for these binding and/or fusion proteins as well as corresponding ve ctors and host cells. Last but not least, the present invention relates to t he use of binding and/or fusion proteins of the present invention for prepar ing a medicament or a diagnostic means as well as to pharmaceutical or diagn ostic compositions comprising said binding and/or fusion proteins.
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