主权项 |
1. A compound of Formula (II): wherein Ra is C1-6alkyl or C2-6alkenyl, each optionally substituted with one or more Rb substituents; C2-6alkynyl; halo; —C(O)Rc; —NRdRe; —C(O)NRdRe; —C(S)NRdRe; —C(═N—OH)—C1-4alkyl; —OC1-4alkyl; —OC1-4haloalkyl; —SC1-4alkyl; —SO2C1-4alkyl; cyano; C3-6cycloalkyl optionally substituted with one or more Rf substituents; or a phenyl, monocyclic heteroaryl, or heterocycloalkyl ring, each ring optionally substituted with one or more Rg substituents;
wherein each Rb substituent is independently selected from the group consisting of —OH, —C1-4alkoxy, —NRdRe, —C(O)NRdRe, —SC1-4alkyl, —SO2C1-4alkyl, cyano, halo, C3-6cycloalkyl, and monocyclic heteroaryl;Rc is C1-4alkyl, —C1-4haloalkyl, C3-6cycloalkyl, or a monocyclic, carbon-linked heterocycloalkyl;Rd is H or C1-4alkyl;Re is H; C1-4alkyl optionally substituted with —CN, —CF3, —OH, or a monocyclic heterocycloalkyl; C3-6cycloalkyl; —OH; or —OC1-4alkoxy;or Rd and Re taken together with the nitrogen to which they are attached form a heterocycloalkyl, optionally substituted with C1-4alkyl or —OH;each Rf substituent is independently selected from the group consisting of: C1-4alkyl optionally substituted with —OH, cyano, or C1-4alkoxy; —OH; halo; C1-4haloalkyl; —CONH2; and cyano; andeach Rg substituent is independently selected from the group consisting of C1-4alkyl, —CF3, halo, —NH2, —OCH3, cyano, and —OH; R1 is selected from the group consisting of H, C1-6alkyl, C1-4haloalkyl, C3-6cycloalkyl, halo, —OC1-4alkyl, —OC1-4haloalkyl, cyano, and —C(O)C1-4alkyl; or Ra and R1 taken together with the carbons to which they are attached form a 5- to 7-membered ring, optionally containing an O or NH, and optionally substituted with one or more Rh substituents;
wherein each Rh substituent is independently —C(O)NRiRj, cyano, or is C1-4alkyl optionally substituted with —OH, —OCH3, cyano, or —C(O)NRiRj; or two Rh groups attached to the same carbon and taken together with the carbon to which they are attached form a carbonyl or a C3-6cycloalkyl;
wherein Ri and Rj are each independently H or C1-4alkyl; R2 is —Rm, —ORm, or —NRmRn;
wherein Rm is aryl or heteroaryl, each optionally substituted with one or more Rs substituents;
wherein each Rs substituent is independently selected from the group consisting of C1-4alkyl, C2-4alkenyl (optionally substituted with halo), C2-4alkynyl, C1-4haloalkyl, C1-4alkoxy, C1-4alkyl-OH, C1-4haloalkoxy, halo, cyano, C3-6cycloalkyl (optionally substituted with —OH or halo), monocyclic heteroaryl, —NH2, —NO2, —NHSO2C1-4alkyl, and —SO2C1-4alkyl;Rn is H, C1-4haloalkyl, or C1-4alkyl optionally substituted with —OH or C1-4alkoxy;
or Rm and Rn taken together with the nitrogen to which they are attached form a pyrrolidine or piperidine ring, optionally substituted with C1-4alkyl and optionally fused to phenyl, wherein said phenyl is optionally substituted with halo; R3 is H or methyl; and R4 is H or fluoro; or a pharmaceutically acceptable salt thereof. |